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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $4,498 | Backorder |
Description | Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced by a high-fat diet+, and can be used in studies of muscle atrophy. |
In vitro | Nicotinamide Riboside Triflate (1-1000 μM; HEK293T cells) exhibits a concentration-dependent increase in intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells.[1] Nicotinamide Riboside Triflate (0.5 nM; 24 h; HEK293T cells) reduces the acetylation status of Ndufa9 and SOD2.[1] Nicotinamide Riboside Triflate enhances NAD levels to reinstate the antiviral poly(ADP-ribose) polymerase (PARP) functions, bolstering innate immunity against coronaviruses (CoVs), a contributing factor to COVID-19.[3] |
In vivo | Nicotinamide Riboside Triflate (400 mg/kg/day; p.o.; for 16 weeks; 10-week-old C57Bl/6J mice) results in tissue-specific increases in both plasma and intracellular NAD+ levels.[1] |
Alias | SRT 647 Triflate, SRT 647, Nicotinamide Riboside, Nicotinamide Ribose, SRT-647, SRT647, SRT647 Triflate, SRT-647 Triflate |
Molecular Weight | 404.32 |
Formula | C12H15F3N2O8S |
Cas No. | 445489-49-6 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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